Parallel Distributed Compensation for Voltage Controlled Active Magnetic Bearing System using Integral Fuzzy Model

Parallel Distributed Compensation (PDC) for current-controlled Active Magnetic Bearing System (AMBS) has been quite effective in recent years. However, this method does not take into account the dynamics associated with the electromagnet. This limits the method to smaller scale applications where the electromagnet dynamics can be neglected. Voltage-controlled AMBS is used to overcome this limitation but this comes with serious challenges such as complex mathematical modelling and higher order system control. In this work, a PDC with integral part is proposed for position and input tracking control of voltage-controlled AMBS. PDC method is based on nonlinear Takagi-Sugeno (T-S) fuzzy model. It is shown that the proposed method outperforms the conventional fuzzy PDC. It stabilizes the bearing shaft at any chosen operating point and tracks any chosen smooth trajectory within the air gap with a high external disturbance rejection capability

Potential cellular and biochemical mechanisms of exercise and physical activity on the ageing process

Exercise in young adults has been consistently shown to improve various aspects of physiological and psychological health but we are now realising the potential benefits of exercise with advancing age. Specifically, exercise improves cardiovascular, musculoskeletal, and metabolic health through reductions in oxidative stress, chronic low-grade inflammation and modulating cellular processes within a variety of tissues. In this this chapter we will discuss the effects of acute and chronic exercise on these processes and conditions in an ageing population, and how physical activity affects our vasculature, skeletal muscle function, our immune system, and cardiometabolic risk in older adults

B6D2F1 Mice Are a Suitable Model of Oxidative Stress–Mediated Impaired Endothelium-Dependent Dilation With Aging

To determine if B6D2F1 mice represent a suitable model of oxidative stress–mediated impaired endothelium-dependent dilation (EDD) with aging, mice were studied at 6.9 ± 0.3 and 31.9 ± 0.6 months. EDD to acetylcholine (ACh) was 26% (p < .001) and 12% (p < .001) lower, respectively, in isolated carotid (n = 10–11) and femoral (n = 10) arteries from older mice, and reductions in arterial pressure to systemic ACh infusion were smaller in older mice (n = 6–10; p < .01). Nitrotyrosine was marked in aorta of older mice (p < .05, n = 4). Superoxide production in carotid arteries was greater (p < .05), and TEMPOL restored dilation in carotid arteries and systemically in older mice. NG-nitro-l-arginine methyl ester (l-NAME) reduced carotid artery dilation in young more than older mice, whereas TEMPOL restored the effects of l-NAME in older mice. Carotid artery stiffness was increased in older compared with young mice (p = .04). Our results provide the first comprehensive evidence that B6D2F1 mice are a useful model for investigating mechanisms of reduced nitric oxide–dependent, oxidative stress–associated EDD and increased arterial stiffness with aging